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基因工程和酵母菌种化学生产的最新进展

Sangdo Yook¹, Hal S Alper^1,2

¹McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, 78712, United States.

FEMS yeast research

|March 14, 2025

概括

通过基因工程和机器学习增强的酵母生物技术,提供生物燃料和化学品的可持续生产. 本次审查强调了推动更绿色生物经济的工具和应用.

科学领域:

生物技术和合成生物学
微生物工程微生物工程

背景情况:

酵母是可持续化学和生物燃料生产的多功能微生物工厂.
基因工具的进步,如CRISPR-Cas和模块化克隆,提高了酵母工程.
基因组规模模型和机器学习加速了基于酵母的生物过程的发展.

研究的目的:

审查用于酵母代谢工程的尖端基因工程工具.
探索酵母平台的各种应用,以生产增值产品.
强调酵母生物技术在促进生物经济中的作用.

主要方法:

对酵母基因工程工具 (CRISPR-Cas,模块化克隆) 的当前文献的综述.
在酵母中探索基因组规模的代谢建模和机器学习应用.
分析生物燃料,有机酸,化物和特种化学品生产中的各种应用.

主要成果:

在传统酵母 (Saccharomyces cerevisiae) 和非传统酵母 (Yarrowia lipolytica,Rhodotorula toruloides,Candida krusei) 的工程方面取得了重大进展.
在生产广泛的化合物方面取得了成功,减少了对化石燃料的依赖.
确定关键的遗传工具和建模方法,推动创新.

结论:

酵母生物技术对于开发石油化学品的可持续替代品至关重要.
基因工程和计算工具的不断进步将进一步扩大酵母的能力.
酵母平台对于建立可持续的生物经济和缓解气候变化至关重要.

关键词:

化学生产化学生产基因工程是基因工程,是基因工程.微生物发酵微生物发酵酵母酵母是一种酵母.

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