执行功能表现在高和低的药物坚持患者与euthymic双极性疾病:一项比较性研究
Mona Rahimi Chahooei1, Komeil Zahedi Tajrishi2, Ghazaleh Zargarinejad1
1Department of Clinical Psychology, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatric), Iran University of Medical Sciences, Tehran Hemat Highway next to Milad Tower, Tehran, Iran.
BMC psychiatry
|March 14, 2025
概括
在双相I型精神障碍中,药物不服药与执行功能障碍有关,特别是在反应抑制和认知灵活性方面. 这些发现强调了评估认知功能的重要性,以改善治疗坚持.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 药物不服药是治疗双相情感障碍的一个重大挑战.
- 认知缺陷,特别是执行功能障碍,在双相情感障碍患者中很常见.
- 在双相情感障碍中,执行功能和药物坚持之间确切的联系仍未得到充分探索.
研究的目的:
- 为了研究执行功能和药物坚持在患有双相I型精神障碍的euthymic患者之间的关联.
- 识别与不遵守相关的特定执行职能缺陷.
主要方法:
- 这是一项涉及200名双相性情绪障碍患者 (年龄在18-55岁之间) 的横截面研究.
- 评估药物坚持使用药物坚持评分表.
- 通过Go/No-Go,威斯康星州卡片排序测试和爱荷华州博任务评估执行职能.
- 用于数据分析的共变量的多变量分析.
主要成果:
- 54.5%的患者表现出较低的药物坚持.
- 低坚持患者在响应抑制 (Go/No-Go) 和认知灵活性 (威斯康星州卡片排序测试) 中表现明显差.
- 在依附组之间没有发现决策 (爱荷华州博任务) 的统计学上显著差异.
结论:
- 在双相I型精神障碍中,低药物坚持与执行功能的缺陷相关,特别是响应抑制和认知灵活性.
- 即使控制了人口统计和临床变量,这些执行职能差异仍然存在.
- 针对执行功能缺陷可能提供一种新的方法,以提高双相情感障碍管理中的药物坚持.
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