孕产妇暴露于甲基和多甲基物质 (PFAS) 和产前症:系统性审查和元分析
Nurliana Abd Mutalib1,2, Juliana Yusof3, Mohd Shahril Ahmad Saman3
1Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Sungai Buloh, Selangor, 47000, Malaysia.
BMC pregnancy and childbirth
|March 14, 2025
概括
母亲接触某些多醇和醇物质 (PFAS),特别是PFOA和PFOS,与产前的风险增加有关. 需要进一步的研究来了解不同的PFAS度和类型.
科学领域:
- 环境健康 环境健康
- 产科和妇科 产科和妇科
- 毒理学 毒理学 毒理学
背景情况:
- 聚甲基和甲基物质 (PFAS) 是持久性有机污染物,疑似与产前有关.
- 关于PFAS暴露与孕前风险之间的关联的现有证据仍然相互矛盾.
研究的目的:
- 系统地审查和进行有关母亲PFAS暴露和孕前的流行病学研究的元分析.
- 评估所选研究的质量,证据的强度和偏见风险.
主要方法:
- 在三个电子数据库中进行了系统的文献搜索.
- 采用随机效应模型的元分析来分析来自7项选定的研究的数据.
- 对每个暴露-结果对进行偏差和异质性风险评估.
主要成果:
- 分析显示,孕妇联合暴露于PFAS和产前之间存在显著的关联,没有异质性.
- 孕产妇暴露在 perfluorooctanoic 酸 (PFOA) 中显示出与产前的中等相关性.
- 孕产妇暴露于甲硫酸盐 (PFOS) 也显示出与孕前风险有显著的关联.
结论:
- 在PFOA和PFOS暴露与患孕前的风险之间发现了显著的关联.
- 进一步深入研究至关重要,以澄清不同的PFAS度和类型对孕前风险的影响.
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