室外空气污染是否导致精液质量低下? 一个系统的审查和元分析
Ria Margiana1,2,3, Hasanain Abdulhameed Odhar4, Kdv Prasad5
1Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
BMC urology
|March 14, 2025
概括
室外空气污染通过减少精液量,精子度和运动性,同时增加DNA碎片化,对男性生育能力产生负面影响. 这一系统性审查强调了空气污染物对精子参数的有害影响.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 流行病学 流行病学
背景情况:
- 越来越多的证据表明,环境因素与生殖健康之间存在联系.
- 空气污染是一种普遍的环境暴露,具有潜在的系统性健康影响.
- 室外空气污染对男性精液参数的影响需要全面评估.
研究的目的:
- 系统地审查和对观察性研究进行元分析,研究室外空气污染与成年男性的精液参数之间的联系.
- 提供空气污染对精液质量关键指标影响的定量总结.
主要方法:
- 在PubMed,Scopus和ISI Web of Science的系统文献搜索相关的观测研究.
- 应用PICO框架 (人口,干预,比较,结果) 来选择研究.
- 对17项研究 (24,065名参与者) 的元分析,使用加权平均差异和置信区间来评估对精液量,精子数,度,运动性,形态和DNA碎片化的影响.
主要成果:
- 暴露于室外空气污染的增加显着与精液体积,精子度,总运动率,渐进运动率和正常形态率的减少有关.
- 随着更高的空气污染暴露,观察到DNA碎片化指数 (DFI) 的显著增加.
- 在几个结局中注意到了实质性的异质性,这表明了跨研究的可变性.
结论:
- 室外空气污染显然会损害成年男性的精子关键参数.
- 这些发现强调了与空气质量相关的潜在生殖健康风险.
- 建议进行进一步的前性队列研究,以阐明潜在的机制并确认这些关联.
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