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Updated: Jul 14, 2026

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单细胞转录组分析揭示了异质性和关键子集,与部状细胞癌中生存和对PD-1阻塞的反应相关

Xia Li1, Zhao Zhao2, Yanmei Cheng2

  • 1Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450052, China. lixia86519@126.com.

Cancer cell international
|March 14, 2025
PubMed
概括

宫平细胞癌 (CSCC) 的瘤微环境 (TME) 是复杂的. PCLAF+瘤相关上皮细胞 (TAEpis) 促进瘤生长并抑制抗PD-1治疗反应.

关键词:
宫支状细胞癌是宫支状细胞癌.异质性 异质性 异质性免疫疗法的反应反应.单细胞RNA测序的一个细胞.与瘤相关的上皮细胞.

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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...