血尿素与肌素比率和阻塞性睡眠呼吸暂停之间的非线性联系:来自NHANESES的横截面研究
Lei Yang1,2, Lanying Li2, TingTing Zeng3
1Department of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou, China.
BMC pulmonary medicine
|March 14, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 与较高的血尿素和肌素比率 (BUCR) 水平有关. 这种关联在糖尿病患者中尤为显著,表明这些疾病之间存在复杂的相互作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肺部病理学 肺部病理学
- 内分泌学 在内分泌学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍的睡眠障碍,经常与代谢状况同时发生.
- 血尿酸与肌素比率 (BUCR) 是评估功能的一个关键指标.
- 需要进一步阐明OSA和BUCR之间的关系.
研究的目的:
- 在成年人中调查阻塞性睡眠呼吸暂停 (OSA) 和血尿素与肌素比率 (BUCR) 之间的关联.
- 探索OSA和BUCR之间的非线性关系和潜在的值效应.
- 检查子组变异,特别是糖尿病的影响.
主要方法:
- 对2005-2008年国家健康和营养检查调查 (NHANES) 数据的分析.
- 使用经过多重共变量调整的逻辑回归模型 (模型III).
- 采用平滑曲线和两部分线性回归来确定值效应和非线性关联.
主要成果:
- 分析了8826名成年人的队列,OSA的流行率为51.3%.
- 经过调整后的分析显示,OSA和BUCR之间存在显著的关联 (OR=1.01,P=0.005).
- 观察到一种非线性关系,BUCR的拐点为10.86;糖尿病显著影响了这一关联.
结论:
- 升高的BUCR水平与OSA的发生率有显著的相关性.
- 糖尿病的存在加剧了BUCR和OSA之间的关联.
- 需要进一步的研究,以了解这种联系在糖尿病人群中的机制和影响.
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