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在肝细胞癌中,SERPINI1 作为促进细胞增殖和侵入的生物标志物

Yawei Han¹, Gaoyv Wang², Erwei Han³

¹Department of Laboratory, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Huanhuxi Road, Hexi District, Tianjin, 300060, PR China.

Cancer cell international

|March 14, 2025

概括

在肝细胞癌 (HCC) 组织和血清中,SERPINI1蛋白质的含量升高,作为潜在的诊断和预后生物标志物. 它的过度表达与生存率差相关,并促进瘤生长和入侵.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生化学

背景情况:

虽然SERPINI1与恶性瘤有关,但其在肝细胞癌 (HCC) 中的作用尚不清楚.
研究SERPINI1在HCC中的特定功能对于了解癌症发展至关重要.

研究的目的:

研究SERPINI1在肝细胞癌 (HCC) 的诊断和预后价值.
探索 SERPINI1 在 HCC 扩散和侵入中的作用.

主要方法:

利用基因表达总量 (GEO) 和基因表达分析交互分析 (GEPIA) 数据库进行表达分析.
执行了接收器操作特征 (ROC) 和卡普兰-梅尔 (KM) 存活分析.
进行了体外实验,包括qPCR,Western blot,MTT,EdU,伤口愈合和Transwell入侵测试.

主要成果:

在HCC组织和血清中,SERPINI1的表达显著增加.
SERPINI1 证明了 HCC 的诊断价值,AFP 和 SERPINI1 组合提高了准确性.
过度表达SERPINI1与较差的整体存活率相关,并促进HCC细胞的增殖和入侵.

结论:

在HCC中SERPINI1的表达很高,并促进瘤的进展.
SERPINI1显示出作为HCC诊断和预后的新生物标志物的潜力.

关键词:

生物标志物生物标志物诊断诊断诊断诊断诊断肝细胞癌是肝细胞癌.在SERPINI1中,我们可以看到

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