功能与2型糖尿病患者全因和因特定死亡率之间的关联:中国的一项前性队列研究
Jialiu He1, Ya'nan Wan2, Xikang Fan2
1Department of Epidemiology and Health Statistics, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China.
Journal of health, population, and nutrition
|March 14, 2025
概括
在2型糖尿病患者 (T2DM) 中,功能异常与较高的死亡率有关. 对eGFR,尿素和尿酸的最佳切断值可以帮助预测T2DM管理中的死亡风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 功能异常是2型糖尿病 (T2DM) 的不良结果的已知危险因素.
- 关于功能标志物与中国T2DM患者死亡率之间的特定关系的证据有限.
研究的目的:
- 研究功能指标 (EGFR,尿素,尿酸) 与中国T2DM患者全因和因特定死亡率之间的关联.
- 确定这些标记物的最佳切断值,以预测死亡风险.
主要方法:
- 一项对19919名中国江苏T2DM患者的队列研究 (2013-2014).
- 基线测量血清估计的淋巴细胞过率 (eGFR),尿素和尿酸.
- 考克斯回归模型和受限立方线分析死亡率关联和剂量反应关系;ROC曲线以获得最佳截止值.
主要成果:
- 在平均9.77年的随访期间,发生了4,428例死亡 (34.8%的心血管疾病,24.3%的癌症).
- 较高的eGFR与较低的全因和心血管疾病死亡率有关;较高的尿素和尿酸与增加的全因死亡率有关 (U型关系).
- 确定了预测所有原因死亡率的最佳截止值:eGFR 88.50 ml/min/1.73m2,尿素 6.95 mmol/L,尿酸 342.50 μmol/L.
结论:
- 异常功能与T2DM患者的死亡风险增加显著相关.
- 需要进一步的临床研究来验证这些发现,并完善功能标志物的使用T2DM死亡风险评估和管理.
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