胎儿泌尿瘤次要的后尿道及其与产后功能的关联:一个多中心的回顾性研究
Flore-Anne Martin1, Matthieu Peycelon2, Nicolas Vinit3
1Department of Gynecology, Obstetrics and Reproductive Medicine, CHU Rennes, Université de Rennes, Rennes, France.
Prenatal diagnosis
|March 14, 2025
概括
带有后尿道 (PUV) 的男性胎儿的产前尿瘤不会恶化产后功能. 这一发现表明,除了已确定的风险因素之外,家长不应该获得额外的负面预后.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 胎儿医学 胎儿医学
- 新生儿病学 新生儿病学
背景情况:
- 产前尿瘤在下泌尿道阻塞 (LUTO),特别是后尿道 (PUV) 中的作用仍在争论中.
- 了解胎儿尿瘤的风险因素及其对产后结果的影响对于准确的预后至关重要.
研究的目的:
- 在被诊断为LUTO和PUV的男性胎儿中确定与胎儿尿瘤相关的风险因素.
- 为了评估产前尿瘤和两岁以下婴儿的功能之间的关联.
主要方法:
- 追溯性,多中心病例控制研究 (2000-2018) 的男性胎儿怀疑LUTO和确认PUV.
- 产前尿瘤是感兴趣的暴露;主要结局是慢性病阶段3+ (CKD3+) 或2岁时死亡.
- 进行了后勤回归分析,包括丢失到后续的患者.
主要成果:
- 在299名患者中,39名 (13%) 患有产前尿瘤. 产前泌尿瘤与产科并发症,胎儿血液样本分析和尿液-羊水突变有关.
- 患有产前尿瘤的患者表现出较高的橄水和扩张后尿道,但尿路感染的发病率较低,尽管DMSA扫描异常更频繁.
- 产前尿瘤与两岁前CKD3+风险增加没有显著相关 (OR=0.56,P=0.23).
结论:
- 产前尿瘤的存在不会对患有PUV的婴儿的功能产生负面影响.
- 咨询未来的父母应该专注于确定的预后不佳的因素,而不是增加过度的警报关于产前尿瘤.
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