转录因子ELF4在生理和疾病中的作用:分子作用和临床影响
Dian Hu1, Zerui Zhang1, Yijun Wang1
1Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Genes & diseases
|March 14, 2025
概括
像ETS转录因子4 (ELF4) 一样,转录因子E74对正常发育和免疫非常重要. 失调的ELF4在癌症中具有双重作用,影响转移和扩散,并显示出作为临床生物标志物的潜力.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 在瘤学瘤学.
背景情况:
- 像ETS转录因子4 (ELF4) 一样,转录因子E74是正常人体组织 (包括造血细胞,卵巢和胎盘细胞) 中的关键调节者.
- 在骨质,脂肪细胞和神经元分化以及免疫系统发育中,ELF4起着至关重要的作用.
- 病理条件可以通过翻译后修改,基因融合和信号交叉声调节ELF4.
研究的目的:
- 提供ELF4分子结构和翻译后修改的全面审查.
- 总结ELF4的生理功能及其在各种疾病中的作用,重点是瘤学.
- 强调ELF4作为预后生物标志物的潜力,并讨论未来的研究方向.
主要方法:
- 对ELF4的分子生物学和临床相关性的文献综述.
- 分析ELF4在癌症中的双重作用,包括瘤抑制和促进.
- 探索ELF4对癌症转移,扩散和瘤微环境的影响.
主要成果:
- 在癌症中,ELF4表现出上下文依赖的功能,同时作为瘤抑制剂和促进剂.
- ELF4显著影响癌细胞转移,增殖和瘤微环境.
- ELF4显示出作为具有临床相关性的预后生物标志物的潜力.
结论:
- 了解ELF4复杂的生物学是其临床转化必不可少的.
- 在癌症中ELF4的双重作用需要进一步研究针对性治疗策略.
- 未来的研究应该集中在ELF4尚未解决的问题上,以释放其全部治疗潜力.
相关概念视频
01:10Transcription
146.2K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
146.2K
02:16Transcription Factors
75.5K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
75.5K
02:35Transcription Elongation Factors
10.6K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
10.6K
02:23Master Transcription Regulators
6.8K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.8K
02:26NF-κB-dependent Signaling Pathway
7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.2K
01:30General Transcription Factors
5.1K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.1K