尼日利亚一家医院的细菌病:实施抗菌素耐药性监测
Adewale A Amupitan1,2, Adeyemi T Adeyemo1,2, Adefunke O Amupitan3
1Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
Journal of public health in Africa
|March 14, 2025
概括
在低收入和中等收入国家 (LMICs) 中,对抗生素耐药性 (AMR) 的监测是可行的和必要的. 这项研究发现,超过一半的血液感染是多药耐药的,这突显了需要强有力的AMR监测来打击死亡率的必要性.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生监督 公共卫生监督
背景情况:
- 抗菌素耐药性 (AMR) 构成了全球健康的重大威胁,需要有效的监测系统.
- 由于资源有限,在低收入和中等收入国家 (LMICs) 实施AMR监测存在独特的挑战.
研究的目的:
- 调查血液感染 (细菌病) 的负担,并描述AMR监测系统的实施.
- 评估LMIC的第三级医疗机构中耐药病原体的流行情况.
主要方法:
- 利用世卫组织的全球抗菌素耐药性和使用监测系统 (GLASS) 发现病例.
- 在2017年5月至2018年6月期间,对血液培养进行了细菌鉴定和抗生素敏感性测试.
- 采用了用于细菌鉴定,抗生素敏感性测试和AMR基因检测的标准协议.
主要成果:
- 在血液培养中确定了19.0%的真实阳性率,污染率为2.2%.
- 流行性耐药病原体包括扩展谱β-乳糖酶 (ESBL) 生产者 (30.2%),AmpCβ-乳糖酶生产者 (5.7%),耐卡巴胺的肠杆菌群 (37.7%),以及耐甲林的黄金葡萄球菌 (MRSA) (50.9%).
- 在医院获得的感染与多药耐药性 (MDR) 细菌病的风险增加有关 (OR=0.3),MDR细菌病与死亡率有显著的关联 (OR=3.8).
结论:
- 多种不同的细菌会导致细菌病,超过一半的细菌会表现出多种药物耐药性.
- 这项研究表明,即使实验室容量有限,医疗保健设施的AMR监测在LMIC中也是可以实现的.
- 这些发现强调了对抗药物耐药性监测倡议的迫切需要,以减轻与MDR细菌血症相关的死亡率.
关键词:
玻璃杯 玻璃杯 的意思尼日利亚 尼日利亚 尼日利亚抗微生物药物耐药性的问题细菌血症的发生医疗保健设施-医疗保健设施实施实施实施实施实施.多种药物耐药性多种药物耐药性监控监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督更多相关视频
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