肠道微生物群与长期BNT162b2疫苗免疫性持久性有关
Ho Yu Ng1, Yunshi Liao2, Ching Lung Cheung3,4
1Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Frontiers in immunology
|March 14, 2025
概括
某些肠道细菌和代谢物与COVID-19疫苗接种后持续的抗体水平有关. 这表明肠道微生物组会影响疫苗的长期免疫性.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 代谢学 代谢学 代谢学
背景情况:
- 随着时间的推移,BNT162b2疫苗的免疫性下降.
- 肠道微生物群和长期疫苗反应之间的关系尚未完全理解.
研究的目的:
- 为了研究基线肠道微生物组成和BNT162b2 COVID-19疫苗的长期免疫性之间的关联.
- 识别与持续抗体反应相关的特定细菌物种,代谢途径和代谢物.
主要方法:
- 在香港对242名成年BNT162b2接种疫苗的前性队列研究.
- 在基线和疫苗接种后180天测量中和抗体 (NAb).
- 使用GC-MS/MS和LC-MS/MS进行肠道微生物组分析和代谢分析的Shotgun DNA元基因组测序.
主要成果:
- 在第180天的高NAb反应与特定的肠道细菌有关,包括Ruminococcus bicirculans,Parasutterella excrementihominis和Streptococcus salivarius.
- 鲁米诺科克斯双环球菌与免疫有益的代谢途径正相关.
- 基线血清丁酸盐和异黄素水平与极高的疫苗反应有显著的关联.
结论:
- 肠道细菌物种,代谢途径和代谢产物与长期的COVID-19疫苗免疫性有关.
- 研究结果表明,肠道微生物组在随着时间的推移中起到调节疫苗有效性的作用.
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