预防性高压氧气疗法通过激活Nrf2/HO-1通路来改善急性移植对宿主疾病
Chao Xue1,2,3, Hao Chen4, Yiou Zhao5
1Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Frontiers in immunology
|March 14, 2025
概括
高压氧疗法 (HBOT) 通过激活Nrf2/HO-1通路,有效治疗急性移植对宿主疾病 (aGVHD). 这项研究表明,HBOT可以降低aGVHD的严重程度并改善存活率,支持其在移植接受者中的使用.
科学领域:
- 移植免疫学 移植免疫学
- 氧气治疗的研究研究.
- 移植与宿主疾病的机制
背景情况:
- 已知高压氧疗法 (HBOT) 在移植受体中治疗出血性囊炎.
- 在治疗急性移植与宿主疾病 (aGVHD) 中,HBOT的作用仍未得到充分探索.
- 这项研究调查了HBOT对aGVHD及其潜在生物通路的影响.
研究的目的:
- 评估HBOT在缓解aGVHD方面的治疗潜力.
- 阐明HBOT影响aGVHD的分子机制.
- 用临床队列研究来验证临床前发现.
主要方法:
- 用一种小鼠模型来评估HBOT对aGVHD表现,病理和生存的影响.
- 分析了活性氧物种 (ROS) 水平和Nrf2/HO-1通路激活.
- 一项临床研究比较了接受HBOT的患者与没有接受HBOT的患者的GVHD发病率.
主要成果:
- 在小鼠中,HBOT显著降低了aGVHD的严重程度,改善了生存率,并减少了病理损伤.
- HBOT降低了ROS和促炎细胞因子的调节,同时提高了Nrf2/HO-1抗氧化途径的调节.
- 临床数据显示,在接受HBOT治疗的患者中,1-3级aGVHD的发病率较低.
结论:
- 通过激活Nrf2/HO-1通路,HBOT显示出对aGVHD的保护作用.
- 在移植患者中,HBOT为预防和治疗aGVHD提供了一个有希望的策略.
- 对于aGVHD管理的HBOT进一步的临床应用是合理的.
关键词:
急性移植与宿主疾病.全源性造血干细胞移植 造血干细胞移植红色素衍生的2相关因子2 (Nrf2)高压氧气疗法 (hyperbaric oxygen therapy) 是一种高压氧气疗法.有活性氧物种的反应性氧物种.更多相关视频
11:55Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
14.5K
09:22Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
Published on: April 2, 2017
14.0K
相关概念视频
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
01:24Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K