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Updated: May 22, 2025

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Published on: August 3, 2018

在固体瘤中,内皮转移到介质细胞的影响是什么:定性系统性审查和定量元分析

Pablo Hernández-Camarero^1,2, Belén Toledo^1,2, Ana Belén Diaz-Ruano^2,3

¹Department of Health Sciences, University of Jaén, Campus de las Lagunillas, E-23071 Jaén, Spain.

International journal of biological sciences

|March 14, 2025

概括

内皮转移到介质酶转移 (EndMT) 驱动了固体瘤的进展和转移. 需要进一步的研究来标准化EndMT模型,并了解其在其他癌症过程中的作用.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
癌症研究癌症研究

背景情况:

内皮转移到介质细胞转移 (EndMT) 越来越被认为是固体瘤进展的关键因素,影响异质性,转移和治疗耐药性.
尽管EndMT具有重要意义,但在癌症研究领域仍未得到充分研究,这突出了关键的知识差距.

研究的目的:

系统地审查关于固体瘤EndMT的文献,重点关注其作用,生物标志物,机制,模型和治疗潜力.
通过元分析确定需要进一步研究的领域,并通过元分析评估EndMT标志物表达变异性和预后联系.

主要方法:

根据PRISMA 2020指南进行了系统审查,搜索了PubMed,Scopus和Web of Science,截至2024年6月.
使用OHAT和SYRCLE工具评估了偏差风险. 一项元分析评估了EndMT标志物表达和患者预后.
从1,197篇初始文章中,通过独立审稿人的严格选和数据提取,选择了54项研究.

主要成果:

终端MT显著促进瘤进展和转移,但其在特定癌症中的诱导,在淋巴内皮细胞中的作用,以及 stromal 相互作用需要更多的研究.
在EndMT生物标志物,内皮细胞类型,功能结果和分子机制中观察到实质性的异质性.
分析显示EndMT生物标志物表达的显著变异性,基因表达变化与患者结果之间的相关性,特别是在肺癌中.

结论:

未来的研究必须确定 EndMT 涉及的特定癌症和 stromal 细胞类型,并标准化内皮细胞模型和诱导协议.
研究EndMT与上皮转移到介质酶转移 (EMT) 和癌症相关纤维细胞 (CAFs) 结合,将对瘤生物学和治疗耐药性产生关键的见解.

关键词:

生物标志物生物标志物与癌症相关的纤维细胞.与终端测试相关的标志物内皮细胞内皮细胞的内皮细胞.内皮细胞到介质细胞的过渡.进行元分析分析.转移转移转移转移治疗目标是治疗的目标.瘤微环境中的微环境

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