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对肺栓塞与慢性炎症疾病患者结局的比较分析
Marlon V Gatuz1, Rami Abu-Fanne1, Dmitry Abramov2
1Department of Cardiology, Hillel Yaffe Medical Center, Hadera, Israel.
International journal of cardiology. Heart & vasculature
|March 14, 2025
概括
由于肺栓塞 (PE) 住院的慢性炎症疾病 (CID) 患者的死亡率较低,但出血风险较高. 这凸显了对这一高风险群体进行个性化治疗策略的需要.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 内部医学 内部医学
背景情况:
- 肺栓塞 (PE) 是死亡的一个重要原因.
- 患有慢性炎症性疾病 (CID) 的患者,如类风湿性关节炎和狼,面临高血栓栓塞事件的风险.
研究的目的:
- 通过CID状态分层研究PE患者的住院结果.
- 分析CID与死亡率,主要心血管和脑血管不良事件 (MACCE) 和出血等结果之间的关联.
主要方法:
- 从国家住院患者样本 (2016-2019) 中对725,725名成人PE患者进行了回顾性分析.
- 根据CID的存在来对患者进行分类.
- 采用多变量逻辑回归模型来调整基线差异.
主要成果:
- 患有CID的患者 (4.6%) 较年轻,更有可能是女性.
- 慢性肺炎与8%的死亡风险降低 (aOR 0.92) 相关,但严重出血风险增加了15% (aOR 1.15).
- 在CID患者中观察到MACCE几率的显著增加 (aOR1.07).
结论:
- 尽管死亡率较低,但患有CID的患者在PE后患有较大的出血风险较高.
- 考虑到患者特定因素的量身定制的治疗方法对于优化这一群体的治疗结果至关重要.
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