克洛托水平之间的关联,KL-VS异构性和精神分裂症的认知
Vijaya Majumdar1, Prosenjeet Chakroborty1, Rashmi Arasappa2
1Molecular Bioscience and Gerosceince lab, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, Karnataka 560105, India.
Schizophrenia bulletin open
|March 14, 2025
概括
克洛托基因变异和蛋白质水平在精神分裂症患者的认知功能中显示出复杂的关联. 这些发现强调了需要谨慎解释Klotho的必要性.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
背景情况:
- 克洛托在与精神分裂症相关的认知功能障碍中的作用尚不清楚,有相互矛盾的证据.
- 这项研究调查了KL-VS基因变异,Klotho蛋白水平和精神分裂症认知表现之间的关联.
研究的目的:
- 探索功能性KL-VS基因变异与精神分裂症患者循环Klotho蛋白水平之间的关系.
- 确定这些因素如何影响认知领域,特别是在认知缺陷患者中.
主要方法:
- 一项涉及239名健康对照和241名精神分裂症患者的病例控制研究.
- 使用神经认知测试评估认知功能,并将患者分为认知缺陷 (CD) 和认知节省 (CS) 组.
- 线性回归模型分析了KL-VS异性 (KL-VSHet+) 和KL水平与疾病状态在认知得分上的相互作用效应.
主要成果:
- 没有观察到KL-VSHet+对认知领域的主要影响.
- 在CD集群中,发现疾病状态和Klotho (基因和蛋白质) 之间的显著负面相互作用对执行功能.
- 在CD集群中发现了对应抑制的相反的积极相互作用,特别是在蛋白质水平.
结论:
- 这项研究揭示了Klotho对精神分裂症认知的影响的复杂和可分离的模式.
- 这些发现表明,关于Klotho对精神分裂症认知的影响的概括结论应该谨慎作出.
更多相关视频
07:04A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
Published on: August 19, 2018
10.4K
05:56Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts
Published on: January 22, 2020
4.7K
相关概念视频
01:09Cytoskeletal Linker Proteins - Plakins
2.2K
Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
2.2K
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:19The Effect of Aging on Tissues
2.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.0K
01:31Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
01:26Aging
34
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
34
02:07Oogenesis
63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K