综合多基因分析确定FUT1是全癌症的预后和治疗生物标志物
Yunqing Liu1, Guanjun Chen1, Xiaotian Yuan2
1Department of Oncology, Third Xiangya Hospital of Central South University, Changsha, 410013, China.
International journal of medical sciences
|March 14, 2025
概括
基转移酶1 (FUT1) 促进癌症的进展,并与许多癌症类型的不良预后有关. 准FUT1可能为各种癌症提供新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 基转移酶1 (FUT1) 是一个高尔基酶,对H抗原前体的产生至关重要,影响瘤相关的糖化和血管生成.
- 虽然FUT1与癌症干,粘附,迁移和耐药性有关,但其泛癌作用,预后意义和分子关联尚未完全理解.
研究的目的:
- 为了全面研究FUT1在不同癌症类型中的表达,预后价值和功能作用.
- 探索FUT1与临床结果,基因组改变,免疫微环境和药物敏感性的关联.
主要方法:
- 使用CCLE,TCGA和GTEx数据库对33种癌症类型中的FUT1表达的系统分析.
- 进行了基因组,功能,免疫微环境和药物敏感性分析.
- 在癌症细胞系中使用FUT1倒置进行实验验证.
主要成果:
- 在不同癌症中,FUT1的表达有显著的变化,与上皮癌,膀泌尿器癌和结肠腺癌的预后不佳相关,并且在直肠腺癌和结肠腺癌中具有诊断价值.
- 基因组分析揭示了与基因组不稳定性相关的频繁FUT1放大,功能分析将FUT1与增殖,转移和上皮-介质细胞过渡 (EMT) 相关联.
- FUT1的表达与免疫细胞透,肌分数,瘤突变负担 (TMB) 和微卫星不稳定性 (MSI) 相相关,并预测了对各种药物的敏感性变化,特别是对氨酸激酶抑制剂的敏感性增加.
结论:
- FUT1是一种潜在的泛癌预后生物标志物,与侵略性瘤特征和改变的免疫微环境有关.
- 抑制FUT1可以抑制癌细胞的扩散和入侵,这表明它具有瘤性作用.
- 这些发现强调了FUT1在瘤学中针对性治疗策略的相关性.
更多相关视频
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...