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单一疗法放射治疗与同时化学辐射之间的比较研究,针对早期喉癌患者进行了选择
Fatma Gharib1, Mostafa Ammar2, Ahmed S Elhamshary2
1Clinical Oncology Department, Tanta University Hospitals Tanta, Egypt.
American journal of cancer research
|March 14, 2025
概括
与照射疗法相比,同时进行化学辐射可显著改善T2喉癌的局部控制和无进展生存率,而仅仅是照射疗法. 这种方法推用于声带运动受损或重疾病的患者.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 辐射瘤学 辐射瘤学
- 医学瘤学 医学瘤学
背景情况:
- 不良的T2喉状状细胞癌带来了高局部失败率的治疗挑战.
- 这些难以治疗的瘤的特点是声带运动障碍和/或重的疾病.
研究的目的:
- 为了比较激进放射治疗和同时化学辐射之间的瘤结局,对于不利的T2喉癌.
- 评估不同治疗方法在管理局部晚期喉癌方面的疗效.
主要方法:
- 一个前性的,开放的,随机的试验,涉及62名患有不良T2喉癌的患者.
- 手臂A:单种疗法放射治疗 (低分离方案65.25 Gy).
- 臂B:并发化疗辐射 (CCRT). 主要终点:局部控制和无进展生存率 (PFS).
主要成果:
- 与放射治疗组相比,同期化疗照射组的局部控制明显高于放射治疗组.
- 在CCRT手臂 (85.5%) 与RT手臂 (57.8%) (P=0.015) 中,三年局部无进展生存率显著更高.
结论:
- 同时的化学辐射证明了对不利的T2喉状状细胞癌的优异结果.
- 应考虑对某些声带运动障碍和/或体积较大疾病的患者进行CCRT,以减轻单独放射治疗相关的高局部失败率.
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