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Updated: May 22, 2025

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通过激活NF-κB信号通路,KAT7通过促进内皮衰老和炎症反应来促进波纳替尼诱导的高血压

Liang-Liang Tang1, Xin-Yu Xu1, Mei Zhang2,3

  • 1Department of Pharmacy and Cardiology, Harbin Medical University (HMU) Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Heilongjiang Key Laboratory for Metabolic Disorders and Cancer related Cardiovascular Diseases.

Journal of hypertension
|March 14, 2025
PubMed
概括

波纳提尼布诱导的高血压与KAT7的增加有关,通过H3K14乙化和NF-κB信号传递引起内皮细胞衰老和炎症. 用WM-3835抑制KAT7改善了高血压和内皮功能障碍.

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