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相关概念视频

Organization of the Brain01:31

Organization of the Brain

The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...

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成年大脑网络分离中的特定年龄和性别模式

Abhijot Singh Sidhu1,2,3,4,5, Kaue T N Duarte2,3,4,5,6, Talal H Shahid2,3,4,5

  • 1Biomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta, Canada.

Human brain mapping
|March 14, 2025
PubMed
概括

随着年龄的增长,大脑网络的分离变得越来越少,这一过程在性别之间存在差异. 女人表现出更分离的关联网络,这表明在成年后更高的效率和专业化.

关键词:
衰老的衰老 衰老的衰老没有分化,没有分化.功能连接性的功能连接性网络隔离 网络分离休息状态的静止状态.性别差异的性别差异.

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科学领域:

  • 神经科学是一个神经科学.
  • 认知老龄化 认知老龄化
  • 功能神经成像 功能神经成像

背景情况:

  • 人类大脑网络分离用于认知和感官处理.
  • 网络隔离随着年龄的增长而减少,这可能与认知能力下降有关.
  • 之前的研究受限于样本大小,空间尺度,年龄范围和性别差异.

研究的目的:

  • 为了全面调查与年龄相关的大脑网络分离的变化.
  • 通过多个空间尺度和特定的功能网络来检查这些变化.
  • 为了解决性别差异在网络重组中的不足研究的作用.

主要方法:

  • 357名参与者 (18-91岁) 的休息状态功能磁共振成像 (fMRI) 数据.
  • 在整个大脑,中间和核心网络 (VIS,SMN,FPN,VAN,DAN,DMN) 层面计算分离指数 (SI).
  • 使用线性回归来评估年龄,性别和互动对SI的影响的统计分析.

主要成果:

  • 在整个成年期复制下降的网络隔离,在全脑,关联,VAN和DMN的特定二次性下降,以及感官网络 (VIS,SMN) 的线性下降.
  • 观察到相邻的关联网络之间以及关联和感官网络之间的偏好功能连接性增加.
  • 确定了显著的性别差异:女性在全脑,关联性,DMN,VAN和FPN中显示出更高的SI;女性减少了关联性网络连接 (DAN-VAN,VAN-FPN).

结论:

  • 功能性大脑网络随着年龄的增长而重组并变得不那么分离,反映了神经脱差或补偿机制.
  • 网络分离的老化轨迹在关联和感官网络之间有所不同.
  • 女人本质上表现出更分离的关联网络,这表明与男性相比,她们的功能效率和专业化更高.