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Updated: May 22, 2025

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

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一种简单的方法,通过在没有基化的情况下进行部分减少,为齐科诺提德分配二硫化物连接性

Peize Wu1, Yuya Cheng1, Weihua Wang1

  • 1Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing, P. R. China.

Rapid communications in mass spectrometry : RCM
|March 14, 2025
PubMed
概括

一种新方法简化了酸盐中的二硫化键连接性分析. 该技术使用部分还原和质谱,准确识别二硫化物桥梁,这对于药用质量控制至关重要.

关键词:
硫化二氧化物连接的连接性液体色谱学 液体色谱学 液体色谱学部分减少部分减少这是一种类.双联质谱质量测量技术

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Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry,...
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