imzML Writer:一个易于使用的Python管道,用于将持续获取的原始质谱成像数据转换为imzML格式
Joseph Monaghan1, Kiera Nguyen1, Nicholas Woytowich1,2
1Department of Chemistry, Vancouver Island University, 900 Fifth Street, Nanaimo, British Columbia, Canada V9R 5S5.
Analytical chemistry
|March 14, 2025
概括
一个新的Python工具,imzML Writer,将供应商格式化的质谱成像 (MSI) 数据转换为标准的imzML格式. 这使新兴MSI技术的用户能够访问先进的图像处理和分析工具.
科学领域:
- 分析化学 分析化学
- 生物技术是生物技术.
- 数据科学数据科学数据科学
背景情况:
- 质谱成像 (MSI) 提供组织中的生物分子的空间分布,产生大型数据集.
- 现有的MSI分析工具通常需要 imzML文件格式的数据.
- 缺乏用于连续获取MSI数据的开放访问,用户友好的转换器.
研究的目的:
- 开发一种可访问的工具,用于将特定供应商的MSI数据转换为imzML格式.
- 为新兴MSI技术提供先进MSI分析软件的使用提供便利.
主要方法:
- 开发 imzML Writer,这是一个具有图形用户界面的 Python 应用程序.
- 集成imzML Scout用于可视化和批量导出离子图像.
- 使用使用卡迪纳尔MSI和METASPACE处理的纳米DESI数据进行演示.
主要成果:
- imzML Writer成功地将供应商数据转换为与像素对齐的 imzML 文件.
- imzML Scout 能够以各种格式对 MSI 数据进行可视化和导出.
- 生成的 imzML 文件与已建立的 MSI 分析平台兼容.
结论:
- imzML Writer为新兴MSI模式的用户提供了一个关键的开放访问解决方案.
- 该工具降低了先进的MSI数据分析的进入壁垒.
- 这项工作支持MSI技术的更广泛采用和使用.
相关概念视频
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