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鉴定一种新型合成甲基CMMP的新型合成甲基

Si-Yang He¹, Qian-Ya Deng¹, Shui-Qing Zheng^1,2

¹Shanghai Key Laboratory of Crime Scene Evidence, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China.

Fa yi xue za zhi

|March 14, 2025

概括

一种结合GC-QTOF-MS,UPLC-Q/Orbitrap HRMS和NMR的新方法成功地确定了一种新型的合成甲基,CMMP. 这种分析方法证实了法医化学中未知的物质的结构.

科学领域:

分析化学分析化学
法医化学法医化学
质谱测量质量谱测量

背景情况:

新兴的合成丁对识别提出了挑战.
准确的结构阐明对于法医分析和公共卫生至关重要.

研究的目的:

开发和验证用于识别未知物质的多技术分析方法.
为了确认一种新型N-摩尔林的结构,用合成丁替代.

主要方法:

气色谱-四极飞行时间质谱 (GC-QTOF-MS).
超高性能液态染色学四极/静电场轨道飞行器高分辨率质谱学 (UPLC-Q/轨道飞行器HRMS).
核磁共振 (NMR) 光谱学.核磁共振 (NMR) 光谱学.

主要成果:

GC-QTOF-MS提供了特征性的离子峰值,基本峰值为m/z 128.1070.
UPLC-Q/Orbitrap HRMS检测到一个质子分子离子峰值在m/z 268.1093.
综合数据证实,未知物质是1 - - - - - - - - - - - - - - - хлорофенил) - - - - - - - - - - - - - - - 甲基 - - - - - - - - - - - - - - - 摩尔福利诺-1- (CMMP),一种新型的合成甲.

结论:

已建立的方法有效地识别了CMMP等新型合成丁.
这种综合分析策略增强了法医科学中的结构性确认能力.

关键词:

1 - - 4 - - 基) - 2 - - 甲基 - - 2 - - 莫尔福林-1- (CMMP)2-甲基-1-[4-(甲基) ]-2-摩尔福林-1- (MTMP) 是一种替代的N-摩尔福林被取代了法医医学法医医学高分辨率质谱仪 (HRMS) 的使用新的精神活性物质 (NPS)合成的卡西诺是一种合成的卡西诺.毒理学分析毒理学分析

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