上呼吸道感染儿童的益生菌和发烧持续时间:一项随机临床试验
Silvia Bettocchi1, Anna Comotti2, Marina Elli3
1Pediatric Unit, Foundation Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
JAMA network open
|March 14, 2025
概括
这项研究发现,益生菌混合物显著降低了患上呼吸道感染 (URTI) 的儿童的发烧持续时间. 益生菌辅助疗法为儿童URTI症状的管理提供了安全有效的选择.
科学领域:
- 儿科医学 儿科医学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 上呼吸道感染 (URTI) 在儿童中很常见,导致频繁的医疗保健访问,特别是伴有发烧时.
- 益生菌正在被探索为URTI的补充治疗方法,但在儿科群体的强有力的证据是有限的.
研究的目的:
- 评估特定益生菌混合物 (Bifidobacterium breve M-16V,Bifidobacterium lactis HN019,Lactobacillus rhamnosus HN001) 在被诊断为URTI的儿童中减少发烧持续时间的有效性.
主要方法:
- 一项随机,双盲,安慰剂控制的临床试验与28天至4岁的儿童进行,这些儿童发烧 (≥38.5°C) 和URTI.
- 参与者每天接受益生菌混合物或安慰剂,持续14天,发烧持续时间是主要结果指标.
- 使用治疗意图分析,参与者,护理人员和调查人员对治疗分配视而不见.
主要成果:
- 这项研究招募了128名儿童,其中63名接受益生菌,65名接受安慰剂.
- 与安慰剂组 (5天) 相比,益生菌组的儿童经历了较短的中位发烧持续时间 (3天),约减少了2天.
- 两组之间没有观察到轻度不良事件 (如便秘或腹痛) 的显著差异.
结论:
- 与安慰剂相比,这种益生菌混合物的使用有效地缩短了URTI儿童的发烧持续时间.
- 益生菌干预表明了有利的安全性,表明其作为儿科URTI辅助治疗的潜力.
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