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Updated: May 22, 2025

Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay
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Published on: September 27, 2024

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对VCP,一个重要的unfoldase和一个deubiquitinase之间的合的结构洞察

Lauren E Vostal1,2, Noa E Dahan1,3, Matthew J Reynolds4

  • 1Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY, USA.

The Journal of cell biology
|March 14, 2025
PubMed
概括

这项研究揭示了蛋白质降解酶含瓦洛蛋白 (VCP) 和二维基酶VCPIP1如何协调其活动. 它们的相互作用使VCPIP1能够去除无素链,帮助蛋白质稳定和器官组织.

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