骨愈合中细胞因子和生长因子动态的计算建模方面的进展:一个范围审查
Ahmad Hedayatzadeh Razavi1,2,3, Nazanin Nafisi1,2,3, Maria Velasquez-Hammerle1,3
1Musculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RN115, Boston, MA, 02215, USA.
Biomechanics and modeling in mechanobiology
|March 14, 2025
概括
审查了骨愈合的计算模型,重点关注生物和机械因素. 数学模型占主导地位,但先进的方法正在出现,突出了关键的增长因素和需要更好的验证.
科学领域:
- 生物医学工程 生物医学工程
- 计算生物学 计算生物学
- 再生医学是一种再生医学.
背景情况:
- 骨愈合是一个复杂的生物过程,受细胞信号和物理力量的影响.
- 了解这些复杂的相互作用对于开发有效的治疗策略至关重要.
- 目前的计算模型旨在模拟和预测骨愈合动态.
研究的目的:
- 系统地审查和综合现有的骨愈合计算模型.
- 分析这些模型中的方法,纳入的生物因素和验证策略.
- 确定该领域的趋势和差距,以指导未来的研究.
主要方法:
- 对71项关于计算骨愈合模型的研究进行了系统范围审查.
- 将模型分类为数学,有限元,基于代理的,机械生物学,药物生物学和混合方法.
- 分析关键细胞因子,生长因子,参数选择和验证技术.
主要成果:
- 数学模型是普遍存在的,但有限元和基于代理的模型越来越多地被使用.
- 关键信号分子如TGF-β,RANK-RANKL-OPG和PTH经常被纳入.
- 在实验验证中存在显著的差距,影响模型可靠性.
- 图书统计分析揭示了骨愈合建模中的有影响力的研究和核心主题.
结论:
- 计算模型是了解骨愈合复杂性的宝贵工具.
- 需要更强大的实验验证,以提高预测准确度.
- 未来的模型应该整合生物和机械因素,以提高临床相关性.
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