用于儿科的复合口服液体的度
Marine Cavelier1, Charles Hervouët2, Rémi Varin3
1Department of Pharmacy, CHU Rouen, Normandie University, UNIROUEN, EA7510 ESCAPE, F-76000, Rouen, France. marine.cavelier@chu-rouen.fr.
European journal of pediatrics
|March 14, 2025
概括
大多数用于儿童的复合口服液体药物具有高度,增加胃肠道风险. 化合物载体,而不是活性成分,是主要原因. 谨慎的车辆选择对于儿科药物安全至关重要.
科学领域:
- 制药科学 制药科学
- 儿科药理学 儿科药理学
- 药物复杂化药物复杂化
背景情况:
- 复合口服液在儿科中是必不可少的,因为缺乏商业可用的儿科配方.
- 口服液体药物的高度可以导致胃肠道并发症.
- 监管机构不评估复合产品的安全性,有效性或质量.
研究的目的:
- 为了评估儿科护理中使用的复合口服液体药物的度.
- 为了确定影响这些化合物药物的度的因素.
主要方法:
- 从机构配方中测量了28种复合口服液体药物的度.
- 收集关于每个药物的活性药物成分和载体的数据.
主要成果:
- 在28种复合药物中,有61%的药物超过了450mOsm/kg的建议度值.
- 化合物中使用的载体是度的主要决定因素.
- 与其他车辆相比,商用车辆与更高的度值有关.
- 活性药物成分对度的影响最小.
结论:
- 载体显著影响复合口服液体的度.
- 必须仔细选择化合物载体,以减少与高度药物相关的风险,特别是对于易受伤害的群体,如通过肠道养的新生儿.
- 系统的度评估可以指导提高复合儿科药物的安全性的策略.
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