相关实验视频

Updated: May 22, 2025

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

鼻上皮层细胞外囊泡与阿司匹林诱导的呼吸反应期间的2型炎症相关

Kaitlyn E Bunn¹, Zachary J Bressman¹, Grant K Nation¹

¹Vanderbilt University Medical Center, Pathology, Microbiology, and Immunology, Nashville, Tennessee, United States.

American journal of respiratory cell and molecular biology

|March 14, 2025

概括

鼻液中的细胞外囊泡 (EV) 在阿司匹林加重呼吸道疾病 (AERD) 期间增加. 这些EV与炎症标志物具有动态相关性,这表明它们在AERD病变发生过程中发挥了作用.

科学领域:

呼吸系统医学呼吸系统医学
细胞生物学细胞生物学
免疫学免疫学免疫学

背景情况:

细胞外囊泡 (EVs) 是细胞通信的关键,但它们在呼吸道炎症中的作用尚不清楚.
了解呼吸系统疾病中的EV变化对于治疗开发至关重要.

研究的目的:

在阿司匹林加重呼吸道疾病 (AERD) 慢性炎症期间调查鼻腔细胞外囊泡 (EV) 种群的变化.
确定在AERD急性恶化期间EVs的动态变化.

主要方法:

用电子显微镜和可调节的电阻脉冲传感器对健康对照组和AERD患者进行了分析.
使用CD14和CD133/1.1.等标记物确定了EV亚群.
在AERD患者的阿司匹林诱导反应期间评估了EV.

主要成果:

在鼻腔内膜液中检测到大量的EV.
在AERD患者中,特定的EV亚群 (CD14+,CD133/1+) 增加.
在急性AERD恶化期间,EV的丰度与cysteinyl leukotrienes和试酶水平相关.

结论:

电动汽车与动态信号网络有关,在AERD中驱动呼吸道炎症.
在AERD患者中,EVs在阿司匹林诱导的2型免疫激活中发挥作用.

关键词:

阿司匹林加剧的呼吸道疾病表面上皮质 (epithelium) 是一个层次的表皮.细胞外囊泡中的细胞外囊泡.莱科特里昂类是什么类型的巨细胞是一个巨细胞.

更多相关视频

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface

Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface

Published on: October 8, 2013

相关概念视频

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.