perfluorobutanesulfonate 干扰肠道重塑 在Lithobates catesbeiana 转变过程中通过下丘脑-垂体-甲状腺轴干扰肠道重塑
Yilin Shu1,2, Qi Wang3, Jun He1
1Collaborative Innovation Center of Recovery and Reconstruction of Degraded Ecosystem in Wanjiang Basin Co-Founded by Anhui Province and Ministry of Education, School of Ecology and Environment, Anhui Normal University, Wuhu 241002, China.
Environmental science & technology
|March 14, 2025
概括
perfluorobutanesulfonate (PFBS) 通过干扰甲状腺激素来破坏两生物的变形,导致肠道不完全重塑. 这种污染物影响激素合成,细胞增殖和分化,这对适应至关重要.
科学领域:
- 环境毒理学环境毒理学
- 发育生物学是发展生物学.
- 两动物的变形过程
背景情况:
- 肠道重塑对于两动物适应各种环境至关重要.
- 普遍存在的污染物 perfluorobutanesulfonate (PFBS) 对这一过程的影响尚不清楚.
研究的目的:
- 为了研究环境相关的PFBS度对两变形期间肠道重塑的影响.
- 阐明涉及甲状腺激素调节和信号通路的潜在机制.
主要方法:
- 在整个变形过程中, (Lithobates catesbeianus) 暴露于不同度的PFBS (0-10μg/L).
- 分析了甲状腺激素水平,基因表达,细胞亡,干细胞增殖和分化.
- 研究了Notch和Wnt的信号通路.
主要成果:
- 暴露于PFBS减少了甲状腺激素的合成和运输,影响了下丘脑-垂体-甲状腺轴和甲蛋白水平.
- 观察到甲状腺激素合成基因的下调和降解酶的上调.
- PFBS诱导了亡,抑制了干细胞的增殖,并阻碍了分化,影响了肠道重塑.
- 由T3调节的Notch和Wnt信号通路被下调,影响了关键的重塑基因 (msi,pcna,lgr5).
结论:
- PFBS通过破坏甲状腺激素平衡和下游信号通路,显著损害两动物的肠道重塑.
- 这项研究提供了PFBS对两动物变形的影响的第一个证据,突出了潜在的生态风险.
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