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Updated: May 22, 2025

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

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与SARS相关的冠状病毒S蛋白结构揭示了协同RBM相互作用,这是高亲和度人类ACE2结合的基础

Jingjing Wang1, Yong Ma1, Zimu Li1,2,3

  • 1Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Research Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

Science advances
|March 14, 2025
PubMed
概括

与严重急性呼吸系统综合征冠状病毒 (SARS) 相关的冠状病毒 (SARSr-CoVs) 与人类血管素转化酶2 (hACE2) 结合,通过新的冷EM结构来澄清. 这些发现揭示了SARSr-CoV尖端蛋白如何通过特定突变获得高亲和度的 hACE2结合.

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Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

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Conjugated Proteins

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Rab Proteins

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Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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