路拉西诱导的晚期运动障碍症通过疗法逆转:一个病例报告
Alice Gelman1, Tamar Jacobsohn1, Hyogun Yi2
1New York University Grossman Long Island School of Medicine, Mineola, NY, USA.
Journal of pharmacy practice
|March 14, 2025
概括
晚期动障碍 (TD),是一种抗精神病药物引起的运动障碍,在治疗后,双相情感障碍患者的症状显著改善. 这表明可能有助于管理TD症状,尽管其作用仍在争论中.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 晚期动症 (TD) 是长期使用抗精神病药物的严重,可能不可逆转的副作用,影响生活质量和治疗坚持.
- 目前的TD治疗选择有限,通过抗精神病治疗方案的修改来预防是主要策略.
- 瓦尔贝纳和维生素E是少数比安慰剂有效的治疗方法之一,但瓦尔贝纳有显著的副作用.
研究的目的:
- 调查在管理晚期运动障碍症 (TD) 中的潜在作用.
- 在患有双极性II障碍的患者中,在增强后TD改善的病例报告.
- 审查关于和TD之间的相互作用的现有文献.
主要方法:
- 一个病例报告,是一名76岁的双相二极性障碍女性,在经过10年的卢拉西治疗后患上了TD.
- 患者每天服用300毫克,经过3年与BD和TD症状作斗争.
- 关于和TD相互作用的文献综述.
主要成果:
- 患者在开始治疗后5周内,TD症状显著改善.
- 在随后的随访中观察到增强的持续益处.
- 该案例表明在TD管理中可能具有治疗作用.
结论:
- 增强可能为迟性运动障碍 (TD) 提供潜在的治疗途径,特别是在对其他疗法耐药的情况下.
- 需要进一步的研究来澄清在TD治疗中的有效性和安全性.
- 在TD管理中的作用仍然存在争议,需要进一步调查.
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