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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
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巴库基醇通过激活GPR120缓解大肠炎.

Fangfang Xu1, Jixia Wang2, Tianyu Zhang3

  • 1Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine, Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, China.

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概括

西申万含有巴库基醇,通过激活GPR120受体,有效治疗炎症性肠病 (IBD). 这项研究确定巴库基醇是IBD的有前途的新型治疗剂.

关键词:
巴库基奥尔 (Bakuchiol) 是一个城市.GPR120 GPR120 是一个很好的方法.炎症性肠病是一种炎症性肠病.西申·万 (Sishen Wan) 是一个中国人.

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科学领域:

  • 药理学 药理学是指药理学的学科.
  • 胃肠病学 胃肠病学
  • 传统中国医药 传统中国医药

背景情况:

  • 西申万 (SSW) 是一种传统的中国草药配方,用于炎症性肠病 (IBD).
  • 在治疗IBD方面,SSW的特定活性化合物和机制在很大程度上是未知的.
  • 这项研究旨在阐明SSW的关键组成部分和行动机制.

研究的目的:

  • 确定Sishen Wan (SSW) 中的主要活性化合物.
  • 在炎症性肠病 (IBD) 模型中评估已识别的化合物的治疗疗效.
  • 探索其抗炎作用背后的分子标和机制.

主要方法:

  • 超高性能液态染色学与质谱学 (UHPLC-MS/MS) 结合用于化学分析.
  • 德克斯硫酸 (DSS) 诱导的大肠炎小鼠模型,以评估治疗效果.
  • 虚拟查,药理分析,RNA测序 (RNA-seq) 和基于细胞的分析以确定分子标和机制.

主要成果:

  • Bakuchiol被确定为SSW的主要活性成分.
  • 巴库奇醇在DSS诱导的大肠炎中显示出显著的治疗效果,与梅萨拉相似或优于它.
  • 巴库基醇作为GPR120激动剂,抑制炎症通路,并部分维持上皮质屏障功能.

结论:

  • 巴库基醇是Sishen Wan (SSW) 中的主要活性化合物.
  • 巴库基醇通过激活GPR120受体在IBD中发挥治疗作用.
  • 巴库基显示出作为一种新型治疗炎症性肠病 (IBD) 的治疗剂的潜力.