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优化in vivo数据采集,以使用超声波定位显微镜进行强大的临床微血管成像
Chengwu Huang1, U- Wai Lok1, Jingke Zhang1
1Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN, United States of America.
Physics in medicine and biology
|March 14, 2025
概括
优化微气泡 (MB) 剂量和超声本地化显微镜 (ULM) 的时间,可以改善微血管成像. 这项研究在猪和人类模型中确定了对微血管系统的一致,可重复的ULM的最佳获取窗口.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 超声波技术 超声波技术 超声波技术
背景情况:
- 超声波定位显微镜 (ULM) 提供超出声波衍射极限的高分辨率微血管成像.
- ULM性能对微泡 (MB) 信号特征如稀疏度,计数和SNR敏感,这些特征在临床玻尿酸注射期间波动.
- 标准化ULM需要优化MB剂量,采集时间和成像参数.
研究的目的:
- 调查猪和人类模型中玻尿酸注射期间MB信号的时间变化.
- 优化微血管学临床ULM的数据采集时间和参数.
- 建立定量指数来评估MB信号质量和指导采集时间.
主要方法:
- 开发的定量指数:MB SNR,正常化交叉相关性 (NCC) 和可定位的MB数量.
- 评估了MB信号质量和本地化性能.
- 探索传输电压和MB剂量对信号质量的影响.
- 在猪和人类模型中分析了MB冲洗期间的时间信号变化.
主要成果:
- MB局部化质量 (NCC) 与MB度相反,在冲洗过程中得到改善.
- 通过平衡本地化质量 (NCC>0.57) 和MB度来确定一个最佳的获取窗口.
- 猪模型在快速冲洗过程中显示了一个短的最佳窗口 (~10秒);由于更慢的冲洗,人类模型具有更灵活的窗口 (1-2分钟).
- 通过较短的获取时间 (3.6-9.6秒) 实现了脏强大的ULM.
结论:
- 在冲洗过程中对MB信号的时间分析对于优化ULM获取至关重要.
- 确定了猪和人类模型的特定最佳获取窗口.
- 在临床环境中证明了强大的ULM的可行性,并优化了获取策略.
- 这些发现支持ULM的标准化和更广泛的临床应用.
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