H2O2/O2 自供应的纳米平台用于放大氧化应激,以加速光动力学/化学动力学治疗周期
Jianying Xi1, Yong Li1, Longhao Lv1
1School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Journal of colloid and interface science
|March 14, 2025
概括
这项研究引入了一种用于联合光动力学和化学动力学治疗的新型纳米复合材料,克服瘤微环境挑战,如缺氧和低过氧化水平,以加强癌症治疗.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 光动力学疗法 (PDT) 和化学动力学疗法 (CDT) 在缺氧瘤中面临挑战,包括低过氧化 (H2O2) 和高谷氨 (GSH) 水平.
- 现有的疗法在瘤微环境 (TME) 中缺乏反应性氧物种 (ROS) 生成.
研究的目的:
- 开发一个核心外纳米复合材料 (UCNP@mSiO2@5-ALA-CaO2-Cu) 用于协同PDT/CDT.
- 为了克服TME的局限性,并通过ROS放大和GSH耗尽来提高抗瘤功效.
主要方法:
- 一种核心外纳米复合材料的制造,集成上转化纳米颗粒 (UCNP),半孔二氧化 (mSiO2),5-aminolevulinic酸 (5-ALA),过氧化 (CaO2) 和铜 (Cu).
- 使用5-ALA产生光敏剂 (原氨酸IX),CaO2为氧和H2O2自给,Cu为芬顿类反应.
- 使用980nm激光启动PDT和基于Cu+的CDT,针对癌细胞和黑色素瘤小鼠模型.
主要成果:
- 纳米复合材料有效地在酸性TME中产生了O2和H2O2,提高了ROS水平.
- 增强的芬顿类反应和GSH无活化导致了放大氧化应激.
- 联合PDT/CDT在体外和体内表现出显著的抗瘤能力.
结论:
- 开发的纳米复合材料通过解决TME挑战,为联合PDT/CDT提供了一个有前途的战略.
- 自给自足的ROS生成和GSH耗尽显著提高抗癌疗效.
- 这种方法代表了一种加速循环策略,用于改善瘤治疗.
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