通过青春期对局部皮质活动的发育脱相关性支持高维编码和工作记忆
Finnegan J Calabro1, Dylan LeCroy2, Will Foran3
1Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Developmental cognitive neuroscience
|March 14, 2025
概括
在青春期,大脑电路变得更加专业化,从而改善认知控制和工作记忆. 这项研究揭示了大脑活动如何改变以支持成人类认知功能.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 认知神经科学 认知神经科学
背景情况:
- 青春期对于认知控制的发展和皮质的细化至关重要.
- 了解本地功能动态如何在此期间改变以支持认知是不完整的.
研究的目的:
- 调查青少年时期在皮层中局部功能连接的变化.
- 将这些变化与认知发展联系起来,特别是工作记忆稳定.
- 探索改变功能专业化的计算影响.
主要方法:
- 利用了134名青少年 (10-31岁) 的纵向静止状态fMRI数据.
- 计算的基于表面的区域同质性 (ReHo) 作为局部功能连接的衡量标准.
- 分析了ReHo,网络本地化,工作内存和编码维度之间的关系.
主要成果:
- 观察到ReHo的广泛下降,表明功能电路专业化增加.
- 发现ReHo降低的空间重叠与传感机动网络和带膜-眼膜网络.
- 相关的ReHo随着工作记忆稳定和更高的内在编码维度而降低.
结论:
- 青少年皮质活动经历了重塑,局部电路变得更加专业化和更高维度.
- 这种专业化增强了大脑对信息编码的能力,支持成人认知功能.
- 研究结果提供了关于青春期认知成熟的基础神经机制的见解.
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