香烟烟雾引起的上皮细胞铁亡促进了鼻多患者的中性友炎症

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Updated: May 22, 2025

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Li Pan¹, Ze Yu¹, Wen-Xuan Xiang²

¹Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, China.

The Journal of allergy and clinical immunology

|March 14, 2025

概括

吸烟会在鼻上皮细胞中触发细胞死亡过程 (ferroptosis). 这促进了鼻息肉 (NP) 的炎症,并强调吸烟是NP发展的危险因素.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
呼吸系统医学呼吸系统医学

背景情况:

表皮细胞死亡调节了呼吸道免疫恒温.
鼻息肉 (NP) 中上皮细胞存活的机制尚不清楚.

研究的目的:

研究鼻上皮细胞中的铁亡.
确定ferroptosis在鼻息肉病原发生中的作用.

主要方法:

通过流细胞计量评估细胞死亡,脂质过氧化和铁水平.
评估了使用RT-PCR,RNA测序,免疫光学和西式涂抹的铁灭生物标志物和途径.
使用香烟烟雾提取物 (CSE) 诱导的小鼠模型和deferoxamine治疗.

主要成果:

鼻息肉表现出铁灭的特征,包括脂质过氧化和线粒体变化.
通过MAPK通路的激活,铁死诱导了CXCL8的产生.
暴露于CSE导致了铁和CXCL8的产生;deferoxamine减轻了这些影响,并减少了小鼠中的中性粒细胞透.
吸烟是NP的重要危险因素.

结论:

吸烟诱导的铁亡促进了鼻上皮细胞中CXCL8的产生.
这种机制可能会加剧鼻息肉中的中性友炎症.

关键词:

铁化是铁化的一种.鼻上皮质细胞鼻上皮质细胞鼻腔多重体是指鼻腔多重体.作为一个中性恋者.吸烟是为了吸烟.

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