醇通过胰岛素/IGF-1信号通路延缓衰老
Hongjiao Zhang1, Jun Xiong2, Qingyao Wang2
1Institute of Life Sciences, Zunyi Medical University, Zunyi Guizhou, 563000, China; College of Basic Medicine, Zunyi Medical University, Zunyi Guizhou, 563000, China; Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Free radical biology & medicine
|March 14, 2025
概括
醇 (Chr) 通过激活胰岛素信号通路,在虫和小鼠中延长寿命和健康期. 这种天然化合物还可以减少衰老标志物,有望治疗与年龄相关的疾病.
科学领域:
- 老年学和分子生物学.
- 药理学和自然产品 药理学和自然产品
背景情况:
- 老龄化是许多疾病的主要危险因素,包括癌症和神经退行.
- 针对保存的衰老途径提供了一个延长寿命和缓解与年龄有关的疾病的策略.
- 醇 (Chr),一种天然的氨酸,已知具有抗癌和抗炎作用,但其抗衰老作用尚未被探索.
研究的目的:
- 研究醇 (Chr) 对模型生物的衰老和寿命的影响.
- 阐明Cr的潜在抗衰老特性背后的分子机制.
- 评估Chr作为治疗年龄相关疾病的候选药物.
主要方法:
- 在Caenorhabditis elegans中进行了寿命和健康期测定.
- 长寿研究在自然衰老,多克索鲁比诱导的衰老和转基因小鼠模型中进行.
- 研究了胰岛素/IGF-1信号通路的参与.
- 分析了与衰老相关的分泌表现型 (SASP) 和抗氧化剂基因表达.
主要成果:
- Chr通过激活DAF-2/DAF-16胰岛素信号通路,显著延长了C. elegans的寿命和健康期.
- 在不同的老化小鼠模型中,Chr促进了长寿,由保留的胰岛素/IGF-1信号通路介导.
- 治疗调节了SASP和高调节了抗氧化剂基因表达,延迟了衰老的表型.
结论:
- 醇 (Chr) 显示出强大的抗衰老作用,从无脊椎动物到哺乳动物都保留了这种作用.
- 该化合物通过进化保守的胰岛素/IGF-1信号通路起作用.
- 是一种有前途的天然产品,用于开发对抗衰老和相关疾病的干预措施.
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