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低氧诱导的线粒体功能障碍和小黄 (Larimichthys polyactis) 中的线粒体食

Lu Deng¹, Jingqian Wang¹, Yang Liu¹

¹Key Laboratory of Applied Marine Biotechnology by the Ministry of Education, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang Province, 315211, People's Republic of China.

Fish & shellfish immunology

|March 14, 2025

概括

像小黄鱼这样的海洋鱼类在低氧压力下激活线粒体吸食来去除受损的线粒体. 这一过程有助于减少活性氧物种 (ROS) 和保持细胞健康,有助于适应低氧环境.

科学领域:

细胞生物学细胞生物学
海洋生物学海洋生物学
环境生理学环境生理学

背景情况:

线粒对于细胞质量控制至关重要,它可以去除受损的线粒体.
在低氧压力下的鱼类中理解菌体是有限的.
缺氧可以诱导氧化应激和线粒体功能障碍.

研究的目的:

为了研究海鱼 (Larimichthys polyactis) 在低氧压力下菌激活的机制.
确定反应性氧物种 (ROS) 在缺氧诱导的线粒体损伤中的作用.
为了阐明细胞适应,涉及对环境低氧的反应中菌体.

主要方法:

在体内 (肝脏) 和体内 (SYCF细胞系) 实验中使用低毒应激.
测量过氧化,ROS和线粒体膜潜力.
分析与髓相关的基因表达 (bnip3,lc3b等). ) 的情况.
超结构检查和线粒体和溶解体的同定位研究.

主要成果:

缺氧压力导致肝损伤,ROS升高,并降低了线粒体膜潜力.
抗氧化剂治疗 (N-乙半氨酸) 缓解了ROS和线粒体损伤.
观察到与线粒细胞衰变相关的基因表达的显著上调.
缺氧诱导了自细胞和自细胞的形成,并增加了线粒体-细胞的共同定位.

结论:

缺氧压力会触发小黄的线粒细胞衰变,以去除受损的线粒体.
在低氧诱导的线粒体损伤中,ROS起着关键作用.
线是海鱼在低氧环境中的关键适应机制.
这些发现支持繁殖耐低氧菌株,并提供了对鱼类适应性的见解.

关键词:

低毒性压力是一种压力.大型鱼多种活动类型线粒体损伤导致线粒体损伤.线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.有反应性氧物种的反应性氧物种.

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