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富可伊丹的输送系统增强了咖啡酸对宫癌的抗癌作用

Xintao Gao¹, Tao Jiang², Xiaochen Wu²

¹Oncology Center I Department, Qingdao Traditional Chinese Medicine Hospital, Qingdao Hiser Hospital Affiliated of Qingdao University, Qingdao 266033, China; College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.

International journal of biological macromolecules

|March 14, 2025

概括

含有咖啡酸的富可伊丹基纳米颗粒通过激活干扰素基因 (STING) 循环GMP-AMP合成酶 (cGAS) -刺激器通路并减少化疗副作用,对宫癌治疗具有前景.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

宫癌是妇女死亡的主要原因之一.
针对循环GMP-AMP合成酶 (cGAS) 刺激干扰素基因 (STING) 途径的免疫疗法提供了一个潜在的治疗策略.

研究的目的:

开发基于fucoidan的纳米颗粒 (Fu/CA NPs) 加载咖啡酸 (CA) 用于宫癌治疗.
调查Fu/CANP的体外和体内疗效.
评估Fu/CANP与西斯普拉丁结合的潜力及其对西斯普拉丁诱导的毒性影响.

主要方法:

以咖啡酸 (Fu/CA NPs) 装载的基于fucoidan的纳米粒子的开发.
使用宫癌HeLa细胞进行体外研究,以评估增殖抑制,亡,活性氧物种 (ROS) 生成,线粒体损伤和cGAS-STING通路激活.
使用小鼠模型进行体内研究,以评估瘤生长抑制和西斯普拉丁联合治疗的影响.
评估思普拉丁诱导的毒性标志物 (血液尿素和血清肌素).

主要成果:

Fu/CA NPs显著抑制了HeLa细胞的增殖 (65.73%) 并通过ROS积累和线粒体损伤诱导了亡.
Fu/CA NPs通过诱导DNA双链断裂和线粒体DNA释放来激活cGAS-STING通路.
在体内,Fu/CA NPs抑制了瘤生长 (67.8%),与西斯普拉丁 (96.5%) 结合时效果得到增强.
组合疗法缓解了西斯普拉丁诱导的毒性,减少了BUN (53.27%) 和SCr (74.93%).

结论:

通过激活cGAS-STING通路,Fu/CA NPs代表了治疗宫癌的一个有前途的治疗剂.
结合Fu/CANP与西斯普拉丁,可以显示出协同作用的抗瘤作用,并减轻化疗引起的损伤.
这项研究提出了一种基于纳米粒子的新策略,用于增强宫癌治疗,降低毒性.

关键词:

咖啡酸是一种咖啡酸.组合化疗是一种化学疗法.福科伊丹是一个子.造成脏损伤的人.

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