对微针贴片作为蛋白质/的输送系统及其在通过皮肤抑制炎症中的应用进行审查
Akshad Balde1, Se-Kwon Kim2, Rasool Abdul Nazeer1
1Biopharmaceuticals Lab, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, Tamilnadu, India.
International journal of biological macromolecules
|March 14, 2025
概括
微针贴片提供了一种微侵袭性方法,可以通过皮肤递送药物,有效治疗炎症性疾病. 这种方法增强了和蛋白质的局部传递,以减少炎症.
科学领域:
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
- 皮肤病学 皮肤病学
背景情况:
- 通过皮肤输送提供了静脉和口服途径的替代方案,因为管理的挑战.
- 基于微针的透皮系统提供了一种侵入性最小的方法,毒理效应降低.
- 像牛皮和关节炎这样的炎症状况可以从向的透皮疗法中受益.
研究的目的:
- 审查微针制造方法,以改善抗炎药物输送.
- 讨论用于和蛋白质输送的微针装置的最新进展.
- 探索微针贴片开发的未来挑战和机会,以抑制炎症.
主要方法:
- 关于微针制造技术的科学文献的综述.
- 对专注于通过微针传递和蛋白质的研究进行分析.
- 讨论开发高效微针贴片的挑战.
主要成果:
- 微针对于局部输送抗炎药物是有效的.
- 当通过微针进行输送时,和蛋白质显示出更好的稳定性和有效性.
- 各种制造方法可以增强药物加载和释放动力学.
结论:
- 微针技术为管理炎症性皮肤疾病提供了一个有希望的策略.
- 优化的微针贴片可以克服和蛋白质的传统输送的局限性.
- 需要进一步的研究来应对制造挑战和临床翻译.
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