无法从主动语义干扰中恢复预测了老年人的日常功能下降的轨迹,这些老年人患有amnestic轻度认知障碍
D Diane Zheng1, Rosie E Curiel Cid2, Alexandra Ortega1
1Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, United States.
International psychogeriatrics
|March 14, 2025
概括
无法从主动语义干扰 (frPSI) 中恢复预测,在患有amnestic轻度认知障碍 (aMCI) 的个体中,功能下降的速度更快. 这一发现有助于预测认知能力下降,并支持早期干预策略.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 老年学是一门学科.
背景情况:
- 麻醉性轻度认知障碍 (aMCI) 是正常衰老和阿尔茨海默病之间的过渡阶段.
- 主动语义干扰 (PSI) 和未能从主动语义干扰 (frPSI) 中恢复,是可能反映潜在神经病理的认知现象.
- 在aMCI的功能衰退的纵向预测对于及时干预至关重要.
研究的目的:
- 评估frPSI和PSI对aMCI患者纵向功能衰退的预测值.
- 为了确定frPSI是否可以预测临床痴呆症评级盒总和 (CDR-SOB) 随着时间的推移的变化.
主要方法:
- 进行了一项纵向前性队列研究,其中97名参与者被诊断患有aMCI.
- 参与者接受了大约38.9个月的3-4次访问的年度评估.
- 使用潜增长曲线建模来估计CDR-SOB的轨迹及其与frPSI和PSI的关联.
主要成果:
- 一个线性增长曲线模型最好地描述了CDR-SOB轨迹.
- 在对共变量进行调整后,frPSI显著预测CDR-SOB下降幅度更大 (β = -0.134,p < 0.01).
- 粉样蛋白状况没有改变frPSI的预测效用.
结论:
- 基线的frPSI是MCI患者日常功能衰退的重要预测指标.
- frPSI在功能变化的纵向预测中表现出实用性,独立于粉样蛋白阳性.
- 这些发现强调了评估frPSI对于预测aMCI的认知和功能轨迹的重要性.
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