情绪对轻度认知障碍主观认知问题的动态影响:一个时间序列网络分析方法
Varsha D Badal1, Laura M Campbell2, Colin A Depp3
1Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Sam and Rose Stein Institute for Research on Aging, University of California San Diego, San Diego, CA, USA.
International psychogeriatrics
|March 14, 2025
概括
在正常认知中,负面影响与以后的主观认知投诉 (SCC) 有着强烈的联系,但在轻度认知障碍 (MCI) 中,这种联系较弱. 生态瞬间评估 (EMA) 有效地测量了MCI中的SCC.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 老年学是一门学科.
背景情况:
- 主观认知投诉 (SCC) 在轻度认知障碍 (MCI) 中普遍存在,并受到情绪状态的影响.
- 了解情绪和SCC之间的相互作用对于认知衰退的准确诊断和管理至关重要.
研究的目的:
- 使用生态瞬间评估 (EMA) 调查情绪状态和SCC之间的关联.
- 探索这些关联如何在正常认知 (NC) 和MCI的个体之间有所不同.
- 评估EMA在MCI中测量SCC的实用性.
主要方法:
- 使用30天EMA协议进行密集的纵向数据收集,每天进行三次调查.
- 网络和时间序列分析以检查影响和SCC之间的同时和时间滞后关系.
- 在48名NC参与者和52名MCI参与者中,对影响和SCC之间的关联进行比较.
主要成果:
- 欧洲药物管理局有效测量了SCC,与MCI中的实验室测量有显著的关联,但不是NC.
- 尽管SCC的平均严重程度相似,但与MCI相比,在NC中SCC的负面影响与MCI相比更强烈.
- 网络分析显示,SCC后期预测的负面影响,NC中比MCI更强的关联.
结论:
- 欧洲药物管理局 (EMA) 是一种潜在有效的方法,用于评估MCI中的SCC.
- 负面影响与随后的SCC有关,特别是在具有正常认知的个体中.
- 在MCI中负面影响和SCC之间的相关性减少,需要进一步调查.
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