维生素E可以改善血中的胆固醇水平,改变肠道微生物群的组成:一项随机对照试验
Bangwei Chen1, Yaxin Li2, Zhiming Li3
1School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China; BGI Genomics, Shenzhen, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|March 14, 2025
概括
维生素E (VE) 补充剂通过降低健康成年人的LDL-C来改善胆固醇水平. 此外,VE也对肠道细菌产生积极影响,这些细菌参与生产短链脂肪酸和代谢胆汁酸.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 人类健康 人类健康 人类健康
背景情况:
- 像维生素E (VE) 和葡萄提取物 (GSE) 这样的抗氧化剂是流行的抗衰老补充剂.
- 肠道微生物群对健康至关重要,并影响干预结果.
- 维埃对肠道微生物群和健康的具体影响仍在调查中.
研究的目的:
- 研究维生素E (VE) 对人类健康的纵向影响.
- 分析 VE 补充剂对肠道微生物群组成的影响.
- 了解VE,肠道细菌和健康标志物之间的相互作用.
主要方法:
- 一项随机对照试验,涉及90名健康个体.
- 参与者被分为三个组:VE治疗,GSE治疗和安慰剂对照.
- 对干预后的身体健康和肠道微生物群变化的纵向评估.
主要成果:
- 维生素E (VE) 补充剂显著降低低密度脂蛋白胆固醇 (LDL-C) 的水平.
- 随着VE的出现,短链脂肪酸 (SCFA) 生产细菌和胆酸代谢物的丰度增加.
- 特定的细菌系如Lachnospira和Faecalibacterium随着VE摄入量增加.
- 对VE反应较差的人表现出更高比例的与疾病相关的细菌.
结论:
- 维生素E (VE) 通过降低LDL-C来促进健康,其间接作用由肠道细菌介导.
- VE影响肠道细菌能够产生SCFA和代谢胆汁酸.
- 准肠道微生物群可能会增强VE补充剂的健康益处.
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