杆菌是否在带出液的中耳炎的发病过程中起作用,或者这是一个谬误? 这就是为什么我喜欢它
Ayse Yasemin Gunduz1,2, Mahmut Tayyar Kalcioglu3, Serdal Celik3
1Department of Otorhinolaryngology, Faculty of Medicine, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Kadikoy, Istanbul, Türkiye. ayaseming@hotmail.com.
概括
这项研究没有发现Helicobacter pylori在中耳溢液或从患有中耳炎与溢液 (OME) 的儿童的腺体样本中存在的证据. 这些发现表明,H. pylori不是OME的活跃病原体.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 儿童传染病 儿童传染病
- 微生物学 微生物学
背景情况:
- 杆菌是已知的慢性系统性感染的原因.
- 它在流出性中耳炎 (OME) 的致病性方面的潜在作用仍然存在争议.
- 之前的研究已经产生了关于H. pylori在OME中的存在的相互矛盾的结果.
研究的目的:
- 为了检测OME儿童的中耳溢液和腺体样本中是否存在Helicobacter pylori.
- 将结果与健康儿童的中耳和腺样本进行比较.
- 为了阐明H. pylori在OME病变发生中的作用.
主要方法:
- 一项前性病例控制研究,涉及300名1-12岁儿童.
- 样本包括中耳喷液,腺体和中耳灌溶液.
- 实时聚合酶连锁反应 (Rt-PCR) 用于检测H. pylori 16S rRNA和23S rRNA基因.
主要成果:
- 在分析的400个样本中 (200个中耳,200个腺体) 没有检测到Helicobacter pylori.
- 这项研究包括一个大样本 (300名儿童).
- 由于没有H.pylori,没有评估克拉里素耐药性.
结论:
- 这项研究提供了强有力的证据,反对Helicobacter pylori作为OME的活性病原体.
- 在OME的背景下,腺体似乎不作为H. pylori的储存库.
- 更新的分子方法证实了OME相关样本中没有H. pylori.
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