营养补充剂参考材料的开发 - 分析挑战,使用,局限性和未来需求
Stephen A Wise1, Sanem Hosbas Coskun2,3, Hugh V Hayes3
1IFC Contractor in Support of the Office of Dietary Supplements (ODS), National Institutes of Health (NIH), Bethesda, MD, 20817, USA. stephen.wise@nih.gov.
Analytical and bioanalytical chemistry
|March 15, 2025
概括
本综述详细介绍了20多年来食补充剂参考材料的发展,强调了分析方面的挑战和在为植物和多维生素产品创建可靠标准方面取得的进展.
科学领域:
- 分析化学 分析化学
- 参考材料 科学 科学 参考材料
- 药理学是指药理学,它是指药理学.
背景情况:
- 国家标准与技术研究所 (NIST) 和国家卫生研究院食补充剂办公室已经合作了20年.
- 这种合作重点是为食补充剂开发关键的参考材料.
- 最初的努力集中在植物和非植物补充剂上,建立基础分析方法.
研究的目的:
- 审查食补充剂参考材料的历史发展和分析挑战.
- 描述从第一代标准参考材料 (SRM) 到第二代认证参考材料 (CRM) 的演变.
- 讨论饮食补充剂参考材料领域的未来需求和进展.
主要方法:
- 开发了20多种植物和多维生素补充剂的标准参考材料 (SRM).
- 应用多种分析技术来赋值标记化合物和有毒元素.
- 复杂的补充矩阵生产中遇到的挑战的审查和分析.
主要成果:
- 成功开发了一系列植物性 (例如,金科,绿茶,大豆) 和多维生素/多矿物质 (MVM) 的SRMs.
- 确定关键的分析挑战,包括矩阵复杂性和复合变性.
- 为下一代CRM建立一个模型,并结合所学到的经验教训.
结论:
- 两十年的合作已经大大提高了食补充剂参考材料的可用性和可靠性.
- 第二代CRM的改进解决了早期材料的局限性,提供了更高的准确性和范围.
- 持续发展对于满足新兴研究领域的补充质量控制的未来需求至关重要.
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