对4例微状结膜炎病例的临床分析
Yang Zhang1, Shanshan Xu2, Yingnan Xu3
1Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China.
Acta parasitologica
|March 15, 2025
概括
微状角膜结膜炎 (MKC) 是一种新出现的眼睛感染. 这项研究报告了中国的四例病例,强调了这种疾病的诊断和治疗策略.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 亚洲人群中越来越多地报告了微状角膜结膜炎 (MKC).
- 关于中国大陆MKC病例的数据有限,特别是在健康人群中.
研究的目的:
- 在中国一所大学医院记录四例MKC病例.
- 协助眼科医生诊断和治疗MKC.
主要方法:
- 四名MKC患者的案例研究.
- 眼科检查,角膜扫描显微镜 (Giemsa,Ziehl-Neelsen,Calcofluor白色斑),培养,以及基因组下一代测序 (mNGS).
- 治疗包括局部 (PHMB,可纳,塔克罗利,氨酸) 和全身 (阿尔本达) 药物.
主要成果:
- 四个病例中,有三例归因于Encephalitozoon hellem,由mNGS证实.
- 常见的症状包括红色,胀,疼痛,异体感觉和视力丧失.
- 确定的风险因素包括隐形眼镜卫生不佳,接触鸟类或受污染的环境. 所有患者在接受治疗后都出现了改善.
结论:
- MKC是一种单边的,急性,非性眼部感染,需要提高临床意识.
- 诊断依赖于临床症状,风险因素评估和实验室检测.
- 综合局部和全身抗原动物治疗已证明有效,尽管需要进一步验证. 建议改善水源管理和个人卫生.
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