全球患病率,代谢特征和瘦肉MAFLD的结果:系统性审查和元分析
Mark C C Cheah1, Harry Crane2, Jacob George2
1Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, New South Wales, Australia. mark.cheah.c.c@singhealth.com.sg.
Hepatology international
|March 15, 2025
概括
瘦个体与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 具有与超重/肥胖患者相似的代谢问题. 然而,瘦肉的MAFLD患者面临与肝脏相关的死亡风险更高.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 越来越多地被发现在瘦个体中.
- 了解瘦肉MAFLD的特征和结果对于公共卫生至关重要.
研究的目的:
- 为了比较患有MAFLD的瘦身患者与超重/肥胖患者的患病率,代谢概况和临床结果.
- 评估这些群体中所有原因,心血管疾病,癌症和肝脏相关事件的死亡风险.
主要方法:
- 对10,013,382个人的数据进行了综合分析.
- 在Embase,Medline和Web of Science的文献搜索一直持续到2023年10月.
- 包括坚持对精益MAFLD的国际共识标准的队列.
主要成果:
- 在一般人群中,瘦肉MAFLD的患病率为1.94%.
- 瘦身和超重/肥胖的MAFLD患者表现出类似的代谢特征 (血压,脂质,葡萄糖,HbA1c).
- 瘦身MAFLD患者的发病率和与肝脏相关的死亡率的可能性显著更高 (OR3.56),但所有原因,心血管和癌症死亡率相似.
结论:
- 与超重/肥胖患者相比,瘦身MAFLD患者的代谢负担和肝外并发症风险相等.
- 尽管整体死亡率风险相似,瘦肉MAFLD与肝脏相关死亡率的风险大幅增加有关.
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