发生性系统性硬化风险中的性别差异:一项全国性基于人口的研究,具有子组分析
Oh Chan Kwon1, Kyungdo Han2, Min-Chan Park3,4
1Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Scientific reports
|March 15, 2025
概括
女性面临的系统性硬化症 (SSc) 的风险明显更高,与男性相比,发病率增加了五倍. 这种更高的风险在没有特定健康状况的中年女性中尤为明显.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 众所周知,全身性硬化症 (SSc) 在女性中更为普遍,但性别之间发生病例的确切风险差异尚未确定.
- 了解基于性别的风险差异对于针对性预防和SSc.早期检测策略至关重要.
研究的目的:
- 量化评估与男性相比,女性发生系统性硬化 (SSc) 的风险.
- 确定基于性别的SSc风险差异最明显的特定人口和临床子组.
主要方法:
- 对一个大规模的韩国全国性队列的分析,包括近1000万个人,从2009年到2019年进行了跟踪.
- 利用考克斯的比例危险模型来比较男女之间的SSc发病率风险.
- 根据年龄,肥胖,体力活动,高血压和脂质失调进行了分组分析,以探索相互作用的影响.
主要成果:
- 与男性相比,女性的事件SSc风险明显更高,调整后危险比率 (aHR) 为5.275.
- 女性的绝对SSc风险为0.025%,男性为0.004%,差异为0.021%.
- 妇女的高风险在中年人群,没有腹部肥胖的人群,有不规则炼习惯的人群和没有高血压或脂质失调的人群中最为突出.
结论:
- 女性患全身性硬化症的风险比男性高得多.
- 性别之间的SSc风险差异在特定的子组中得到放大,包括中年人以及某些生活方式或并发症概况的人.
- 这些发现强调了将性别视为SSc风险评估和管理中的关键因素的重要性.
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