来自400多个实验室热暴露研究中的热引起的心脏功能变化的元分析
Robert D Meade1,2, Ashley P Akerman3, Sean R Notley3
1Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada. rmeade@hsph.harvard.edu.
Nature communications
|March 15, 2025
概括
热浪会增加心血管疾病的风险. 使用封装加热的实验室研究显示,与自然暴露的热量相比,心脏压力过度,突出了需要现实的研究.
科学领域:
- 环境生理学环境生理学
- 心血管生理学心血管生理学
- 气候健康 气候健康
背景情况:
- 热浪与心血管死亡率的增加有关.
- 现有关于热量对心脏影响的研究经常使用人工加热方法,如透水西装.
- 了解心脏对自然热暴露的反应对公共健康至关重要.
研究的目的:
- 综合现有关于人类对暴露于热量的心脏反应的研究.
- 为了比较封装和自然热暴露模拟之间的心脏反应.
- 提供热浪期间生理反应的经验数据.
主要方法:
- 对400多项基于实验室的热暴露研究 (1961-2024) 的元分析.
- 包括6858个参与者暴露.
- 多层混合效应建模用于分析心血管和温度数据.
主要成果:
- 核心温度和心率的中位数分别增加了0.9°C和27bpm.
- 封装式加热方式导致心率,心脏输出和心脏工作量增加.
- 封装方法也导致系统性血压的大幅下降.
结论:
- 实验室发现可能会高估由于人工加热方法造成的心脏应变.
- 对于准确的气候健康模型来说,现实的热暴露研究至关重要.
- 在全球气温上升的情况下,需要更好地了解有效的热健康指导.
相关概念视频
Responses to Heat and Cold Stress
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
Body Temperature
Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C (97–99°F), remaining relatively stable...
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C (97–99°F), remaining relatively stable...
Homeostatic Imbalances in Body Temperature
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...


