增加了默认模式网络功能连接的个体变异性及其遗传相关性在大型抑郁症中
Chi Yao1,2, Peng Wang1, Yang Xiao3
1Center for Cognition and Brain Disorders/Department of Neurology, The Affiliated Hospital, Hangzhou Normal University, No.2318, Yuhangtang Rd, Hangzhou, Zhejiang, China.
Scientific reports
|March 15, 2025
概括
大型抑郁症 (MDD) 在默认模式网络 (DMN) 中显示出可变的大脑连接. 在MDD患者中增加的DMN功能连接与症状严重程度相关,这表明潜在的生物标志物应用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 重度抑郁症 (MDD) 是一种具有显著个体变异性的异质状况.
- 这种变化可能源于大脑网络的改变,特别是默认模式网络 (DMN).
研究的目的:
- 在MDD患者中,研究DMN与其他大脑区域之间功能连接 (IVFC) 的个体变异性.
- 确定与MDD相关的IVFC异常及其临床相关性.
- 探索IVFC与基因表达模式之间的相关性.
主要方法:
- 分析了796名MDD患者和823名健康对照者的休息状态功能磁共振成像 (rs-fMRI) 数据.
- 检查DMN与108个非DMN区域之间功能连接 (IVFC) 的个体变异性.
- 与临床分数 (抑郁症汉密尔顿评分表 (HAMD)) 和基因表达数据的相关性分析.
主要成果:
- 在MDD患者和HC患者中,在DMN内观察到类似的IVFC空间模式.
- 患有MDD的患者在一些区域显著增加IVFC,包括腹中前额叶皮质,前带皮质,后带皮质, fusiform gyrus和皮质.
- 在DMN和状圈中的平均IVFC与HAMD得分正相关.
- 基因表达分析发现了与膜潜能调节和突触传输等过程的显著关联,解释了47.0%的IVFC变异.
结论:
- 个人在DMN功能连接的变化是MDD的一个关键特征.
- 在MDD患者中,特定的IVFC变化与症状严重程度有关.
- DMN IVFC变异性具有作为MDD的神经成像生物标志物的潜力.
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